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The darker side of misdiagnosis. This month in Health Matters, we bring our attention to depression and hypothyroidism. Although they are two separate diseases, depression can be a symptom of hypothyroidism, which is a deficiency in the levels of hormones created by your thyroid gland. The medications prescribed to increase low thyroid levels can often alleviate the many symptoms of hypothyroidism, including depression. Joint or muscle pain or cramps. Dryness or yellowing of the skin.